College of Massage Therapists of British Columbia (CMTBC) Practice Exam

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Which of the following statements is true regarding DHT?

It is less potent than testosterone
It is converted from testosterone in peripheral tissues
It is primarily produced in the testes
It inhibits the effects of testosterone

The correct answer is: It is converted from testosterone in peripheral tissues

The statement that Dihydrotestosterone (DHT) is converted from testosterone in peripheral tissues is accurate. DHT is synthesized from testosterone through the action of the enzyme 5 alpha-reductase, which is found in various tissues, including the skin and the prostate. This conversion process enhances the biological activity of testosterone because DHT is actually more potent than testosterone in binding to androgen receptors, leading to significant effects in target tissues. Understanding the process of DHT formation highlights its role in various physiological functions and conditions related to androgen activity, such as hair loss and prostate health. The other statements provided do not hold true: DHT is not less potent than testosterone; although it is produced in various tissues, its primary production occurs in the skin and prostate rather than the testes alone; and it does not inhibit testosterone's effects but rather exerts its own effects that can be similar or sometimes more pronounced.