Where do antibodies arise from in the human body?

Antibodies are proteins produced by a specific type of white blood cell known as B cells. These B cells originate and mature in the bone marrow. When B cells encounter an antigen, they can differentiate into plasma cells, which are responsible for producing antibodies specific to that antigen.

While the spleen and lymph nodes are important sites for the immune response where B cells can further differentiate and encounter antigens, they do not produce antibodies directly. The thymus is involved in the maturation of T cells, another crucial component of the immune system, but it is not responsible for the production of antibodies. Therefore, the bone marrow is the primary site where the production of antibodies occurs.