College of Massage Therapists of British Columbia (CMTBC) Practice Exam

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Leydig (interstitial) cells secrete which hormone?

Estrogen
Progesterone
Corticosterone
Testosterone

The correct answer is: Testosterone

Leydig cells, also known as interstitial cells, are located in the testes and play a crucial role in male reproductive physiology. These endocrine cells are primarily responsible for the production and secretion of testosterone, which is the main male sex hormone. Testosterone is essential for the development of male secondary sexual characteristics, such as increased muscle mass, body hair growth, and the deepening of the voice, as well as playing a vital role in spermatogenesis. Understanding the specific function of Leydig cells highlights their importance in the endocrine system of males. The other hormones listed—estrogen, progesterone, and corticosterone—are associated with different functions and tissues, such as female reproductive health and adrenal function, but are not secreted by Leydig cells. This critical distinction underscores why testosterone is correctly identified as the hormone secreted by Leydig cells.